Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous.

Autonomous in the Absence of CTLA-4 Is Not T Cell Cutting Edge: Lymphoproliferative Disease

Cryptococcosis : a model for the understanding of infectious diseases

The Journal of Clinical Investigation http://www.jci.org Volume 124 Number 5 May 2014 1893 immune responses mounted by CTLA-4-deficient T cells: a paradigm reconsidered. Eur J Immunol. 2001; 31(2):450–458. 8. Bachmann MF, Kohler G, Ecabert B, Mak TW, Kopf M. Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous. J Immunol. 1999;163(3):1128–1131. 9. Liu Y. I...

Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease.

It is generally acknowledged that cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4/CD152) plays a pivotal role in the regulation of T-cell activation and the establishment of self-tolerance in the periphery. CTLA-4-deficient (CTLA-4KO) mice develop a lymphoproliferative disorder and die within 4 weeks of birth, suggesting a role for CTLA-4 in T-cell homeostasis or the development and activit...

Normal responsiveness of CTLA-4-deficient anti-viral cytotoxic T cells.

CTLA-4 has been proposed to negatively regulate immune responses, and mice deficient for CTLA-4 expression succumb to a lymphoproliferative disorder within a few weeks after birth. This study assessed the responsiveness of CTLA-4-deficient T cells expressing a class I-restricted TCR specific for lymphocytic choriomeningitis virus (LCMV). The kinetics of T cell proliferation were studied in vitr...

Lack of Association between Promoter Gene Polymorphism (-318 C/T) and Multiple

Multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system is believed to have a T cell-mediated autoimmune etiology. The cytotoxic T lymphocyte antigen 4 (CTLA-4) gene is a strong candidate for the involvement in autoimmune diseases. To examine the genetic association of the CTLA-4 gene locus with MS, in a case-control design, we analyzed (-318 C/T) sin...